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- Interaction between p53 and Bcl-2 family members Bcl-2 inhibitor, Nutlin-3, ABT-263, ABT-737, Pomalidomide. By:-Behrendt Koski
Several studies about the interactions of p53 using Bcl-2 proteins revealed that stress-induced p53 can bind to Bak, release that from an inhibitory complex with Mcl-1, leading to oligomerisation and activation of Bak. For Bax, p53 can directly promote its service. Pomalidomide. With the assistance of Puma, the initial complexity of stress-induced p53-Bcl-xL is usually disrupted, and sufficient numbers of active p53 are released to promote apoptosis. In another approach, p53 can bind to Ku70, a DNA maintenance protein, disrupt the connection of Bax-Ku70, and result in Bax activation and apoptosis. In addition to the interactions with Bax and Bak, p53 is capable to interact with another pro-apoptotic Bcl-2 pet Bad.
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